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Established in 2000, the Donovan McNabb Fund (formerly known as the Donovan McNabb Foundation) has trumpeted the awareness and prevention of diabetes. Millions of dollars have been raised and distributed to the American Diabetes Association. The Fund was started as a means to honor some of Donovan’s close family members, including his father Sam, who have been diagnosed with diabetes.
Each year the ADA hosts the Donovan McNabb Diabetes Camp for Kidsthrough the foundation’s funding. The week-long resident stay at Camp Green Lane in Montgomery County, Pennsylvania, open to diabetic boys and girls ages 8-16, offers a wide range of activities, including swimming, sports, hiking, arts and crafts, theater, music and campfire activities.
On October 20, 2009, Donovan and Raquel McNabb announced a partnership with Virtua Hospital making a six-figure donation to help with the construction of the new NICU at the Virtua Voorhees replacement hospital, which opened in 2011. In addition, the family is committed to helping raise $2.5 million for additional funding for the project. The completed unit has been named The McNabb Family Neonatal Intensive Care Unit in honor of their dedication and commitment. Despite moving from the area, Donovan and Raquel remain committed to Virtua and the South Jersey area. They served as co-chairpersons at Virtua's Annual Gala at The Borgata in Atlantic City in both 2010 and 2011.
The DM5 Fund has also hosted an annual All-Star Football Clinic. This football drills clinic is open to a few hundred 11-16 year olds and is run by Donovan and his father, and some of his NFL friends and coaches. The first two years the clinic was held in Donovan’s hometown of Chicago before seven years at the Eagles NovaCare Complex. In 2010, the camp moved to the Memorial Sports Complex, in Marlton, NJ.
Some of the funds raised by the DM5 Fund have gone to education in the form of scholarships and through donations to Mt. Carmel High School and Syracuse University - two institutions that he continues to financially support. In 2000, he began the Donovan McNabb Golden Arm Scholarship, for students who maintain a 2.5+ GPA at Mt. Carmel. In 2008, the McNabb's made a personal donation to Syracuse University whereby the lounge for the Women's Basketball Team was named for Donovan and Raquel McNabb.
The Donovan McNabb Fund has also supported the American Red Cross, the United Negro College Fund, the Associated Services for the Blind & Visually Impaired, the Children’s Crisis Treatment Center, Children’s Hospital of Philadelphia, Temple University Children’s Medical Center, the Ronald McDonald House, the School District of Philadelphia, the Philadelphia Free Library, the Police Athletic League, the Fraternal Order of Police, Hurricane Katrina Relief, Xavier University and Dillard University.
For Thanksgiving and Christmas each year, the Donovan McNabb Fund and well as the McNabb Family have made contributions in the form of food, clothing and presents to bring joy and cheer to numerous needy Philadelphia families. In 2008, the DM5 Fund hosted the “Super 5 Bowl.” As an addition to the annual DM5 Christmas Party, Donovan hosted 120 children from the Philadelphia and Camden areas to a private bowling party with food and presents for all attendees. On December 17, 2009, despite a Philadelphia-record snowfall, Donovan hosted his annual McNabb Christmas Party joining forces with Sonny DiCrecchio, a local philanthropist, and Pete Ciarrocchi, owner of Chickie & Pete's Sports Bars, to provide a Shopping Spree & Wrapping Party for over 125 kids from Stenton Family Manor. After selecting presents for their immediate families, the kids were chaperoned to PLAY2, an interactive gaming emporium, to wrap their gifts, eat, play and have their picture taken with Donovan and Santa. 
As a result of hosting their annual Thanksgiving Dinner at Stenton Manor, the McNabb’s were responsible for the adoption of Stenton Manor by the Philadelphia Region Produce Market. That adoption has resulted in the family shelter receiving more than $75,000 each year in fresh fruits and vegetables.

With a change in location in 2010, the holidays were not much different for the McNabbs in terms of supporting their community. At Thanksgiving, they provided entire meals of turkey (over 2,000 pounds), stuffing, mac & cheese, greens, fresh fruits and vegetables to over 100 families selected by Martha's Table, a community center that helps at-risk children, youth, families and individuals in the Washington, D.C., community improve their lives by providing educational programs, food, clothing and enrichment opportunities. At Christmas time, Donovan joined forces with the Redskins and their annual Toys for Tots program. Donovan made the largest individual financial contribution and recorded a PSA imploring Redskins fans to make donations. The results - the 'Skins most successful holiday event with over 3,500 kids in the DC Metro area receiving gifts at Christmas.
Donovan and DM5 Fund continue to support the communities he grew up in and the ones in which he raises his family. The 2011 season was no different as the DM5 Fund found ways to bring the holiday spirit to Minnesota. 
In 2007 and 2009, Donovan’s wife Raquel McNabb hosted her Philadelphia Community Baby Shower. The event, paid for by the DM5 Fund, helped expectant and new mothers through the transition of having a baby. The event provided education from participating hospital nurses, health care advocates, as well as products and gifts for new parents to ease the financial burden.
In 2009, Donovan continued a program providing a pair of tickets to each Eagles home game to a Philadelphia area high school football player who exhibits outstanding effort on and off the field along with leadership and great character. With the help of the Eagles organization, the player and his chaperone visit the field for pregame warmups and get a chance to meet Donovan after the game.
The Fund has raised money through various means. In the past that has included cocktail dinners, Dine-A-Rounds, concerts, softball games, and golf tournaments.
Donovan, his family, and the Foundation have been recognized over the years for their support. Some of the awards include: the ADA Father of the Year (2009); the McNabb Family was honored by the ADA for their contribution to the fight against diabetes (2006); Humanitarian of the Year by the Chamber of Commerce - South Jersey (2007); was recognized at the UNCF Annual Gala for his contributions to Dillard University and Xavier University in support of Hurricane Katrina victims (2006); the Children's Crisis Treatment Center for his commitment to enrich the lives of children (2004); NFLPA's Perseverance Award (2004); named Most Caring Athlete by USA WEEKEND Magazine (2003); the Wanamaker Award, given to the athlete or team that has done the most to reflect credit upon Philadelphia and their team or sport (2002).